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HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.
Singhal R, Mitta SR, Das NK, Kerk SA, Sajjakulnukit P, Solanki S, Andren A, Kumar R, Olive KP, Banerjee R, Lyssiotis CA, Shah YM. Singhal R, et al. J Clin Invest. 2021 Jun 15;131(12):e143691. doi: 10.1172/JCI143691. J Clin Invest. 2021. PMID: 33914705 Free PMC article.
Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by the transcription factors hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha. .. …
Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and confers resistance to chemo and radioth …
Metabolic phenotypes in pancreatic cancer.
Yu M, Zhou Q, Zhou Y, Fu Z, Tan L, Ye X, Zeng B, Gao W, Zhou J, Liu Y, Li Z, Lin Y, Lin Q, Chen R. Yu M, et al. PLoS One. 2015 Feb 26;10(2):e0115153. doi: 10.1371/journal.pone.0115153. eCollection 2015. PLoS One. 2015. PMID: 25719198 Free PMC article.
METHODS: We performed Immunohistochemical staining of GLUT1, CAIX, BNIP3, p62, LC3, GLUD1, and GOT1. Based on the expression of metabolism-related proteins, the metabolic phenotypes of tumors were classified into two categories, including glucose- and glutamine-dependent m …
METHODS: We performed Immunohistochemical staining of GLUT1, CAIX, BNIP3, p62, LC3, GLUD1, and GOT1. Based on the expression of metab …
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Li W, Chen C, Zhao X, Ye H, Zhao Y, Fu Z, Pan W, Zheng S, Wei L, Nong T, Li Z, Chen R. Li W, et al. J Cell Mol Med. 2017 Nov;21(11):2896-2908. doi: 10.1111/jcmm.13202. Epub 2017 May 24. J Cell Mol Med. 2017. PMID: 28544376 Free PMC article.
In this study, we noted that HIF-2alpha expression was significantly up-regulated in PDAC, positively associated with disease stage, lymph-node metastasis and patient survival, and identified as an independent prognostic factor of PDAC patients. ...Furthermore, we noted th …
In this study, we noted that HIF-2alpha expression was significantly up-regulated in PDAC, positively associated with disease stage, lymph-n …
SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.
Wong CC, Qian Y, Li X, Xu J, Kang W, Tong JH, To KF, Jin Y, Li W, Chen H, Go MY, Wu JL, Cheng KW, Ng SS, Sung JJ, Cai Z, Yu J. Wong CC, et al. Gastroenterology. 2016 Nov;151(5):945-960.e6. doi: 10.1053/j.gastro.2016.07.011. Epub 2016 Jul 21. Gastroenterology. 2016. PMID: 27451147 Free article.
Knockdown of SLC25A22 in KRAS mutant CRC cells reduced their proliferation, migration, and invasion in vitro, and tumor formation and metastasis in mice, compared with cells without SLC25A22 knockdown. ...Incubation of KRAS mutant CRC cells with knockdown of SLC25A22 with …
Knockdown of SLC25A22 in KRAS mutant CRC cells reduced their proliferation, migration, and invasion in vitro, and tumor formation and met …